Change of life: The change of life is the menopause, the time in a woman's life when menstrual periods permanently stop. Menopause is the opposite of the menarche. Menopause is defined as the time when there has been no menstrual periods for 12 consecutive months and no other biological or physiological cause can be identified. It is the end of fer... Found on http://www.medterms.com/script/main/art.asp?articlekey=8942